Article Dans Une Revue Polyhedron Année : 2025

Homo- and hetero-dinuclear CpFe and CpRu complexes of a 1,2,4-triazo-le-bis-Cp ligand with anticancer potential

Résumé

A homo- and a hetero-dinuclear organometallic complex, [(Cp)Fe(Cp)-CH(Tz)-(Cp)M(Cp)] (M = Fe (3a), Ru (3b); Cp- = cyclopentadienyl, Tz = 1,2,4-triazole), were prepared from carbinol precursors [(Cp)Fe(Cp)-CH(OH)-(Cp)M(Cp)] (M = Fe (2a), Ru (2b), and 1,2,4-triazole. Complexes 3a-b were characterized by 1H and 13C NMR spectroscopy, mass spectrometry (MS), and elemental analysis. The X-ray crystal structure of 3a reveals two ferrocenyl units, whereas 3b exhibits two Fe/Ru mixed-occupancy metal sites in a 1:1 ratio, along with disorder in the pendant Cp units in both structures. These findings are consistent with the MS data, which clearly show the [M]+ ion for 3a (Fe/Fe) and 3b (Fe/Ru), but no Fe/Fe or Ru/Ru species for 3b. The antiproliferative activities of 3a and 3b were evaluated against HeLa, MCF-7, and HT-29 cancer cell lines, with IC₅₀ values ranging from 14 to 95 μM. For comparison, cisplatin exhibited IC₅₀ values between 0.33 and 22 μM under the same conditions.

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Dates et versions

hal-05216433 , version 1 (20-08-2025)

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I. Almendras, M. Gallardo, Pascal Roussel, Natacha Henry, A. Steinbrueck, et al.. Homo- and hetero-dinuclear CpFe and CpRu complexes of a 1,2,4-triazo-le-bis-Cp ligand with anticancer potential. Polyhedron, 2025, Polyhedron, 279, ⟨10.1016/j.poly.2025.117648⟩. ⟨hal-05216433⟩
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